Crowdsourced genealogies and genomes
نویسندگان
چکیده
منابع مشابه
Germs, genomes and genealogies.
Genetic diversity in pathogen species contains information about evolutionary and epidemiological processes, including the origins and history of disease, the nature of the selective forces acting on pathogen genes and the role of recombination in generating genetic novelty. Here, we review recent developments in these fields and compare the use of population genetic, or population-model based,...
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The relationship between the evolution of a set of genomes and of individual loci therein could be very complex. For example, in eukaryotic species, meiotic recombination combined with effects of random genetic drift result in loci whose genealogies differ from each other as well as from the phylogeny of the species or populations—a phenomenon known as incomplete lineage sorting, or ILS. The mo...
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Developers change source code to add new functionality, fix bugs, or refactor their code. Many of these changes have immediate impact on quality or stability. However, some impact of changes may become evident only in the long term. This thesis makes use of change genealogy dependency graphs modeling dependencies between code changes capturing how earlier changes enable and cause later ones. Us...
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Mueller and Tribe [32] have shown that rescaled long-range voter models in onedimension converge to a Wright-Fisher SPDE, also known as a stochastic FisherKolmogorov-Petrovskii-Piscounov (FKPP) wave. Recently Hallatschek and Nelson [20] have described the asymptotic behavior of genealogies in a closely related model. Their answer is expressed in terms of a diffusion in a very singular random en...
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Phylogentic analysis is becoming an increasingly important tool for customized drug treatments, epidemiological studies, and evolutionary analysis. The TCS method provides an important tool for dealing with genes at a population level. Existing software for TCS analysis takes an unreasonable amount of time for the analysis of significant numbers of Taxa. This paper presents the TCS algorithms a...
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ژورنال
عنوان ژورنال: Science
سال: 2018
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aat2634